New Genetically Homogeneous Background for Dystrophic Mice and Their Normal Counterparts

See allHide authors and affiliations

Science  23 Mar 1962:
Vol. 135, Issue 3508, pp. 1061-1062
DOI: 10.1126/science.135.3508.1061


A new type of genetically homogeneous dystrophic and comparable normal mice, from an F1 hybrid cross between 129/Re-dy and C57BL/6J-dy, is now available as a result of a special breeding program. The clinical manifestations in these F1 hybrid dystrophics correspond closely with those observed in 129/Re-dydy mice, and they give completely comparable results on a variety of research tests. They are, however, considerably healthier than previously available dystrophics, with a growth rate closer to normal and a greatly increased life-span.