Action of 1,1,Dichloro-2-p-chlorophenyl-2-o-chlorophenylethane on Dog Adrenal Cortex

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Science  06 Apr 1962:
Vol. 136, Issue 3510, pp. 47
DOI: 10.1126/science.136.3510.47


A single intravenous injection of op'DDD (1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane) has an acute effect on the adrenal cortex of the dog. Within 2 hours after intravenous injection of the drug, there is a decrease in the in vitro response of the adrenal cortex to stimulation by adrenocorticotrophic hormone and an inhibition of glucose-6-phosphate dehydrogenase activity. The inhibition of glucose-6-phosphate dehydrogenase activity might explain the effect of op'DDD on corticosteroid production.

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