Patterns of Gene Pleiotropy in Morphogenetic Processes

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Science  17 Aug 1962:
Vol. 137, Issue 3529, pp. 538-540
DOI: 10.1126/science.137.3529.538


Selection for an increase and decrease in the expression of the ocelliless mutant in Drosophila subobscura, variable for the number of ocelli and bristles, has revealed the pleiotropic nature of the mutant. In addition to modifying a morphogenetic system responsible for the formation of ocelli and bristles, it also modifies another morphogenetic system determining the positions of these structures, at the extreme range of the mutant expression.