Staggerer, a New Mutation in the Mouse Affecting the Cerebellum

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Science  24 Aug 1962:
Vol. 137, Issue 3530, pp. 610-612
DOI: 10.1126/science.137.3530.610


The "staggerer" mutant is recognized by its staggering gait, mild tremor, hypotonia, and small size. Symptoms develop during postnatal weeks 1 to 4 and remain stationary thereafter. The cerebellar cortex is grossly underdeveloped, with too few granule cells and unaligned Purkinje cells. Genetic linkage studies and neuropathological findings distinguish staggerer from other known mutants.

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