Autoimmune Response in Rabbits Injected with Rat and Rabbit Liver Ribosomes

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Science  31 Aug 1962:
Vol. 137, Issue 3531, pp. 688-689
DOI: 10.1126/science.137.3531.688


Autoimmune hemolytic anemia and leukopenia, circulating autoantibodies for erythrocytes, leukocytes, and ribosomes; pathological changes in liver, spleen, heart, brain, and kidneys were produced in rabbits injected with rat or rabbit liver ribosomes. The hematologic and pathologic changes were reproduced by injection of anti-ribosomal serum into normal rabbits. The autoantibody specificity was related primarily to nucleotides and nucleosides.