Placebo Effect in the Rat

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Science  09 Nov 1962:
Vol. 138, Issue 3541, pp. 677-678
DOI: 10.1126/science.138.3541.677


Scopolamine hydrobromide disrupts the learned behavior of rats in a predictable manner. Physiological saline mimics to some extent the effect of the drug when the two substances are alternately administered in a series of injections. This placebo effect appears to be an instance of simple Pavlovian conditioning.

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