Antigenicity of Polypeptides: Immunological Unresponsiveness to Copolymers of α-Amino Acids

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Science  15 Mar 1963:
Vol. 139, Issue 3559, pp. 1061-1062
DOI: 10.1126/science.139.3559.1061-a


Immunological tolerance toward three synthetic random copolymers of the α-amino acids, glutamic, lysine, alanine, and tyrosine, was produced by a single injection of the polymers into newborn rabbits. The tolerant state could be extended by an additional intravenous injection of antigen. Repeated injections of the polymer in adjuvant mixture could "break" the tolerant state.