Antigenic Determinants in Fragments of Gamma Globulin from Rabbit Serum

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Science  29 Mar 1963:
Vol. 139, Issue 3561, pp. 1292-1293
DOI: 10.1126/science.139.3561.1292


Peptic digestion of fraction III from papain-digested rabbit serum γ-globulin produces a variety of smaller fragments. Some are too large to pass through a dialysis bag, and these retain the capacity to precipitate with antiserum to rabbit γ-globulin. Others pass through the bag and fail to precipitate with antibody, but they can inhibit the precipitation of antibody with fraction III. This indicates that antigenic determinants of the γ-globulin molecule are carried in these fragments.