Antibody Quality after Sequential Immunization with Related Antigens

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Science  26 Apr 1963:
Vol. 140, Issue 3565, pp. 405-406
DOI: 10.1126/science.140.3565.405-a


The response to the second antigen of a sequence of two related antigens appears to consist of two qualitatively different antibody populations. Antibodies specific for the second antigen are of primary-response quality while the antibodies which cross-react with the first antigen are of secondary-response quality.