Genetic Control of Differential Heat Tolerance in Two Strains of the Nematode Caenorhabditis elegans

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Science  19 Jul 1963:
Vol. 141, Issue 3577, pp. 266-267
DOI: 10.1126/science.141.3577.266


Two strains (Bergerac and Bristol) of the nematode Caenorhabditis elegans, with different temperature tolerances, were reared axenically at 23° to 25°C. The Bergerac strain is heat sensitive (that is, it is sterile at maturity), whereas the Bristol strain is heat resistant (that is, it matures and reproduces normally). Hybrid hermaphrodites (F1), produced by crossing Bristol males and Bergerac hermaphrodites, are heat tolerant. Heat sensitivity segregates as a simple Mendelian recessive in the F2 and F3 generations.

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