Congenital Malformations in Hamster Embryos after Treatment with Vinblastine and Vincristine

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Science  02 Aug 1963:
Vol. 141, Issue 3579, pp. 426
DOI: 10.1126/science.141.3579.426


Intravenous injection of vinblastine or vincristine, two antitumor chemotherapeutic agents used in humans, into pregnant golden hamsters on the 8th day of gestation, causes an increase in the fetal mortality rate and the appearance of a significant number of congenital malformations in the surviving fetuses.

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