Dialysis Studies in Rats on the Long-Acting Antimalarial CI-501

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Science  23 Aug 1963:
Vol. 141, Issue 3582, pp. 723-724
DOI: 10.1126/science.141.3582.723


Through the use of dialysis sacks, containing the repository antimalarial CI-501, implanted intraperitoneally into rats, evidence has been obtained indicating a local rather than a systemic reservoir of the drug. These results suggest that the repository activity of CI-501 is due to drug release from the injection site and that the probability of toxic effects resulting from storage or accumulation of the drug in vital organs is remote.