Thymectomy: Prolongation of Immunological Tolerance in the Adult Mouse

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Science  20 Sep 1963:
Vol. 141, Issue 3586, pp. 1193-1194
DOI: 10.1126/science.141.3586.1193


The loss of acquired immunological tolerance of mice to bovine gamma globulin depended on the presence of the thymus. Mice were repeatedly injected with bovine γ-globulin from birth until the age of 5 to 10 weeks and then thymectomized or sham operated. After 130 to 160 days without antigen, an accelerated (immune) disappearance of I125 bovine γ-globulin could be uniformly induced in controls while thymectomized mice remained tolerant. Adult thymectomized mice made tolerant by a single injection of bovine γ-globulin lost tolerance more slowly than sham-operated controls.

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