Spontaneous Autoimmunity in Mice: Antibodies to Nucleoprotein in Strain A/J

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Science  20 Mar 1964:
Vol. 143, Issue 3612, pp. 1333-1334
DOI: 10.1126/science.143.3612.1333


An antibody to nucleoprotein, which appears to be an autoantibody, occurs in the γ-globulin fraction of serum from mice of the A/J strain. This antibody combines with nucleoprotein of several species but not with calf thymus DNA. The frequency of its occurrence increases with age and is greater in females. Serums that contain the antibody produce typical lupus erythematosus cells in vitro.