Thalidomide: Effects on Enzymes of Glutamic Acid Metabolism in Mice

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Science  20 Mar 1964:
Vol. 143, Issue 3612, pp. 1343-1344
DOI: 10.1126/science.143.3612.1343


Thalidomide caused no significant alteration in the activity of glutamic decarboxylase in extracts of brain or of glutamic dehydrogenase or glutamic oxalacetic transaminase in extracts of brain or liver when added in vitro or injected into normal mice. Administered to pregnant mice, thalidomide had no effect on the activity of the latter enzymes in extracts of embryos with adhering uterus tissue.