Estrogen Administered Neonatally Affects Adult Sexual Behavior in Male and Female Rats

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Science  10 Apr 1964:
Vol. 144, Issue 3615, pp. 185-187
DOI: 10.1126/science.144.3615.185


The injection of 100 µg of estradiol benzoate into female rats 96 hours after birth abolished sexual receptivity in adulthood, even with estrogen and progesterone replacement after ovariectomy. The administration of testosterone propionate to these animals in adulthood elicited the full pattern of male sexual behavior. The same dose of estrogen given to male rats 96 hours after birth produced adults which were unable to achieve intromission, although they mounted as frequently as normal animals. Testosterone replacement after castration in adulthood reproduced this abnormal behavior.

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