Gamma-Globulin Affinity for Normal Human Tissue of the Central Nervous System

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Science  29 May 1964:
Vol. 144, Issue 3622, pp. 1141-1142
DOI: 10.1126/science.144.3622.1141


Immunofluorescent staining of the serum and cerebrospinal fluid of patients with and without neurological disease demonstrates an affinity of the gamma-globulin fraction for glial cells and myelin sheaths in normal human nervous tissue. This affinity appears to be specific for the 7S gamma-globulin fraction and is not seen with the other major protein fractions of serum and cerebrospinal fluid or with the fluorescein conjugated antisera alone.

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