Lymphoid Organs and Normal Gamma-Globulin in the Rat

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Science  05 Jun 1964:
Vol. 144, Issue 3623, pp. 1219-1220
DOI: 10.1126/science.144.3623.1219


Serum gamma-globulin was determined in adult rats several months after total thymectomy, subtotal splenectomy, or a combination of total thymectomy, subtotal splenectomy, and subtotallymphadenectomy. The thymus apparently is of little importance in the production of normal gamma-globulin, but it may influence the production of albumin because a reduction of serum albumin was only seen in groups where thymectomy was performed. The spleen seems to produce normal gamma-globulin to a greater extent than lymphoid tissue elsewhere in the body.