Staphylococcal Alpha-Hemolysin: Detection on the Erythrocyte Membrane by Immunofluorescence

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Science  14 Aug 1964:
Vol. 145, Issue 3633, pp. 714-715
DOI: 10.1126/science.145.3633.714


Purified staphylococcal α-hemolysin (but not the toxoid) was demonstrated on the surface of rabbit and human erythrocytes by immunofluorescence. This occurred during the period of maximal hemolysis and was a transient event. These findings have been analyzed in relation to previous data on the kinetics of leakage of both small and complex molecular constituents of the erythrocyte.