Fetal Death from Nicotinamide-Deficient Diet and Its Prevention by Chlorpromazine and Imipramine

See allHide authors and affiliations

Science  25 Sep 1964:
Vol. 145, Issue 3639, pp. 1429-1430
DOI: 10.1126/science.145.3639.1429


Feeding a diet deficient in nicotinamide, nicotinic acid, and tryptophan to pregnant rats causes death and resorption of all fetuses. This effect can be prevented by administration of either chlorpromazine or imipramine. Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.