Genetic Regulatory Mechanisms at the Population Level in Man

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Science  13 Nov 1964:
Vol. 146, Issue 3646, pp. 924-925
DOI: 10.1126/science.146.3646.924


The distribution of the Rhesus and ABO blood groups, thalassemia, and glucose-6-phosphate dehydrogenase deficiency in Europe and in Jewish populations argues for a regulatory mechanism at the population level which adjusts gene frequencies so that the overall genetic load is not excessive, since gene frequencies giving a high genetic load at one locus are often associated with those giving low genetic loads at other loci.