Allergic Encephalomyelitis: A Hyperacute Form

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Science  25 Dec 1964:
Vol. 146, Issue 3652, pp. 1681-1682
DOI: 10.1126/science.146.3652.1681


The hyperacute form of allergic encephalomyelitis is characterized by its short incubation period, 100 percent incidence, overwhelming severity, and high mortality and by the massive quantities of polymorphonuclear neutrophils, fibrin, and edema fluid which infiltrate the central nervous system. The hyperacute form has been produced with the aid of aqueous pertussis vaccine as an adjuvant. This is the first reproducible laboratory model for human acute necrotizing hemorrhagic encephalopathy.