Ethylation: Biological Formation of an S-Ethyl Homolog of Lincomycin

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Science  25 Dec 1964:
Vol. 146, Issue 3652, pp. 1691-1692
DOI: 10.1126/science.146.3652.1691


Streptomyces umbrinus var. cyaneoniger produces the antibiotic lincomycin. When grown in the presence of ethionine an additional antibiotic is produced. Physical and chemical analyses and incorporation of radioisotopes indicate that the new antibiotic is the S-ethyl homolog of lincomycin.