Polypeptide Chains of Antibody: Effective Binding Sites Require Specificity in Combination

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Science  05 Feb 1965:
Vol. 147, Issue 3658, pp. 613-615
DOI: 10.1126/science.147.3658.613


Separated chains from antibody of different rabbits do not always give effective binding sites although combination of the chains does occur. There is a specificity of combination such that only chains from the same (or perhaps a related) rabbit form effective binding sites. There appears to be preferential combination between those chains which yield effective sites.