Immunoassay for Human Chorionic "Growth Hormone-Prolactin" in Serum and Urine

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Science  12 Feb 1965:
Vol. 147, Issue 3659, pp. 751-753
DOI: 10.1126/science.147.3659.751


Chorionic "growth hormone-prolactin" in serum and urine from pregnant women, in serum from umbilical cord, and in amniotic fluid was assayed by a sensitive immunological method dependent on the combination of rabbit antiserum to the growth hormone-prolactin with the iodine-131-labeled hormone. The hormone is detectable in serum and urine early in gestation, and with advancing pregnancy its concentration in serum continues to increase to a maximum during the last trimester. It was not found in serum within 8 hours after delivery.

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