Circulating DNA as a Possible Factor in Oncogenesis

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Science  16 Apr 1965:
Vol. 148, Issue 3668, pp. 374-376
DOI: 10.1126/science.148.3668.374


Infectious DNA from the tumor-inducing polyoma virus and pneumococcal-transforming DNA can be recovered from the blood of mice in biologically active form after intraperitoneal injection. Polyoma DNA appeared to undergo less inactivation than did transforming DNA. In light of these observations, the metastatic spread of cancer may possibly be favored by circulation of tumorigenic DNA in the blood stream.

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