Chromosomal Breakage in a Rare and Probably Genetically Determined Syndrome of Man

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Science  23 Apr 1965:
Vol. 148, Issue 3669, pp. 506-507
DOI: 10.1126/science.148.3669.506


A high frequency of chromosomal breakage and rearrangement has been found in cultured blood cells from six of seven individuals with a rare syndrome characterized by congenital telangiectatic erythema and stunted growth. Only 19 instances of this apparently genetically determined disorder are known, and malignant neoplasia has developed in three.