Gallstones Produced Experimentally by Lithocholic Acid in Rats

See allHide authors and affiliations

Science  04 Jun 1965:
Vol. 148, Issue 3675, pp. 1339-1340
DOI: 10.1126/science.148.3675.1339


Administration of lithocholic acid (1 percent in the diet) consistently produces choledocholithiasis in 8 weeks in rats on an 8-percent protein diet. The gallstones consist predominantly of the calcium salts of free and glycine-conjugated lithocholic and 3α,6β-dihydroxy-5β-cholanic acids. Conjugation of bile acid with taurine can be enhanced and stone formation can be inhibited by an increase in the dietary protein or by a diet supplemented with taurine.