Pancreatic Secretion Induced by Stimulation of the Pyloric Gland Area of the Stomach

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Science  04 Jun 1965:
Vol. 148, Issue 3675, pp. 1347-1348
DOI: 10.1126/science.148.3675.1347


Pure gastrin I of Gregory and Tracy stimulated secretion not only of gastric acid but also of pancreatic fluid and protein material. Similarly, endogenous release of gastrin from a transplanted pouch of the pyloric gland area of the stomach, initiated by irrigation with solutions of acetylcholine, stimulated gastric acid secretion and pancreatic flow and protein output in dogs with fistulas of both organs. The effect on the pancreas, like that on the stomach, was inhibited by acidification of the acetylcholine solution.