Control of Enzyme Activity in Growing Bacterial Cells by Concerted Feedback Inhibition

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Science  04 Jun 1965:
Vol. 148, Issue 3675, pp. 1351-1353
DOI: 10.1126/science.148.3675.1351


Amino acids of the aspartic acid family are synthesized in bacteria through a multistep branched pathway. In the photosynthetic bacterium Rhodopseudomonas capsulatus, the enzyme that catalyzes the first step is specifically inhibited by a combination of two end-product amino acids. Evidence is presented for operation of this kind of "concerted" feedback control as a regulatory device in growing cells.