Homograft Rabbit Skin Protection by Phenothiazine Derivatives

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Science  11 Jun 1965:
Vol. 148, Issue 3676, pp. 1468-1469
DOI: 10.1126/science.148.3676.1468


Rejection of homografts of rabbit skin can be delayed by treatment with either chlorpromazine, perphenazine, or promethazine. Promethazine can also delay rejection of second-set homografts. The membrane protective action of these phenothiazine derivatives appears to be the most likely mechanism of this activity.