Particles Resembling Papova Viruses in Human Cerebral Demyelinating Disease

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Science  11 Jun 1965:
Vol. 148, Issue 3676, pp. 1477-1479
DOI: 10.1126/science.148.3676.1477


Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.