Cleft Palate Produced in Mice by Human-Equivalent Dosage with Triamcinolone

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Science  20 Aug 1965:
Vol. 149, Issue 3686, pp. 862-863
DOI: 10.1126/science.149.3686.862


Triamcinolone produced cleft palates in mouse embryos at a dosage proportionate, by body weight, to common therapeutic dosage for humans. Thus, it showed much greater teratogenicity than other glucocorticoids tested on mice. Widely ranging doses of desoxycorticosterone did not produce cleft palates.