Actinomycin D and Hydrocortisone: Intracellular Binding in Rat Liver

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Science  10 Sep 1965:
Vol. 149, Issue 3689, pp. 1251-1254
DOI: 10.1126/science.149.3689.1251


DNA was found to be the major intracellular binding site for labeled actinomycin D administered in vivo. In analogous studies, hydrocortisone did not bind to nuclear structures. Furthermore, following the administration of actinomycin D, a highly positive correlation was found between the RNA content of the nucleus and the ability of the nucleus to synthesize RNA.

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