Chondroitin Sulfate: Inhibition of Synthesis by Puromycin

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Science  10 Sep 1965:
Vol. 149, Issue 3689, pp. 1263-1265
DOI: 10.1126/science.149.3689.1263


Puromycin reversibly inhibits synthesis of chondroitin sulfate by vertebral chondrocytes from 10-day-old chick embryos. Treatment of these cells with puromycin for 5 hours does not affect viability or capacity to multiply on subsequent release from their matrix. It is suggested that synthesis of this polysaccharide is coupled with that of protein; there may be a feedback control in its synthesis.

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