Actinomycin D: Inhibition of Protein Synthesis Unrelated to Effect on Template RNA Synthesis

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Science  24 Sep 1965:
Vol. 149, Issue 3691, pp. 1504-1506
DOI: 10.1126/science.149.3691.1504


Incubation of sarcoma-37 ascites cells in vitro with actinomycin D resulted in inhibition of synthesis of nuclear and cytoplasmic proteins. The overall inhibition could be prevented or relieved by glucose; it is thus unrelated to breakdown of template RNA.