α-Hydroxy Acid Oxidase: Localization in Renal Microbodies

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Science  24 Sep 1965:
Vol. 149, Issue 3691, pp. 1507-1509
DOI: 10.1126/science.149.3691.1507


Differential and density equilibrium centrifugation have established the presence of α-hydroxy acid oxidase in microbodies of the kidney of the rat. The enzyme has been demonstrated in cells of the distal convoluted tubule by a microscopic cytochemical method. This enzyme, like certain others in microbodies, produces hydrogen peroxide.