Leukocyte Alkaline Phosphatase: Electrophoretic Variants Associated with Chronic Myelogenous Leukemia

See allHide authors and affiliations

Science  01 Oct 1965:
Vol. 150, Issue 3692, pp. 58-60
DOI: 10.1126/science.150.3692.58


Starch-gel electrophoresis of leukocyte alkaline phosphatases, rendered soluble by treating normal leukocytes with butanol, revealed three electrophoretic variants of the enzyme. The phosphatases in similarly prepared extracts of leukemia cells differed from the normal isozymes in electrophoretic. mobility. A single variant was detected in one case of untreated leukemia; a similar component and three additional ones were seen in leukemia treated with 6-mercaptopurine.