Effect of Gamma Radiation on Dietary and Hormonal Induction of Enzymes in Rat Liver

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Science  12 Nov 1965:
Vol. 150, Issue 3698, pp. 901-903
DOI: 10.1126/science.150.3698.901


The dietary induction of serine dehydrase, produced by the oral intubation of hydrolyzed casein to protein-depleted rats, is markedly inhibited by doses of γ-radiation of 400 roentgens or higher provided the irradiation is given within an hour after the initial dose of casein. If the irradiation is delayed until 7 hours after the initial dose of casein, induction is not inhibited. In contrast, the cortisone induction of tyrosine α-ketoglutarate transaminase is not inhibited by doses of γ-radiation up to 3200 roentgens; in some instances hormonal induction of this enzyme appears to be enhanced by irradiation.