Genetic Factors and Polypeptide Chain Subclasses of Human Immunoglobulin G Detected in Chimpanzee Serums

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Science  03 Dec 1965:
Vol. 150, Issue 3701, pp. 1293-1294
DOI: 10.1126/science.150.3701.1293


The Gm and Inv genetic factors, characteristic antigens of human immunoglobulin G, were detected in chimpanzee serums. All animals tested were Gm(a+, x—, bl—, b2—, b3+, b4+). Polymorphism was demonstrated for factors Gm(c), Inv(l), and Inv(b). Three of the subclasses of heavy polypeptide chains and both types of light polypeptide chains that are present in human immunoglobulin G were identified in chimpanzee serums.