Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes

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Science  14 Jan 1966:
Vol. 151, Issue 3707, pp. 209-210
DOI: 10.1126/science.151.3707.209


Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.

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