Restoration of Gamma Globulin Production in Agammaglobulinemic Chickens

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Science  28 Jan 1966:
Vol. 151, Issue 3709, pp. 471-473
DOI: 10.1126/science.151.3709.471


Chickens irradiated and bursectomized in the newly hatched period consistently develop agammaglobulinemia and form no circulating antibodies; if the birds are treated immediately after operations by intra-abdominal injection of unirradiated autologous bursa cells, immunoglobulin production, lymphoid germinal centers, and plasma cells are restored; however, the birds fail to produce antibody to specific antigenic challenge.

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