Antagonism of Purified Asparaginase from Guinea Pig Serum toward Lymphoma

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Science  25 Feb 1966:
Vol. 151, Issue 3713, pp. 998-999
DOI: 10.1126/science.151.3713.998


The tumor inhibitory activity of highly purified asparaginase from guinea pig serum toward the Gardner lymphosarcoma in C3H mice was compared with that of the serum itself. The purified enzyme, homogeneous by ultracentrifugation and immunoelectrophoresis, had activity comparable to that of the serum. The serum was also effective in mice which were made immunologically incompetent by radiation with coba't-60.