Rubella Virus: Growth and Cytopathic Effect in Primary Cultures of Cells of Rabbit Embryos

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Science  18 Mar 1966:
Vol. 151, Issue 3716, pp. 1405-1406
DOI: 10.1126/science.151.3716.1405


Primary cultures of rabbit (New Zealand white) embryo cells support growth of rubella virus. Distinct cytopathic changes are discernible within 6 to 8 days after inoculation. This cell system has been successful for the recovery of rubella virus from clinical materials and the demonstration of neutralizing antibody in patient serum.