Actin-Myosin Interaction: Inhibition of the Myosin Adenosine Triphosphatase by Actin

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Science  25 Mar 1966:
Vol. 151, Issue 3717, pp. 1541-1542
DOI: 10.1126/science.151.3717.1541


In the absence of magnesium ion, the addition of actin to myosin in a 1 :4 ratio has a strong inhibitory effect on the adenosine triphosphatase activity, in contrast to the well-known activating effect of actin in the presence of magnesium ion. This finding suggests that both effects result from a conformational change in the active site of the myosin adenosine triphosphatase.

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