Intestinal Alkaline Phosphatase: Regulation by a Strain-Specific Factor in Mouse Milk

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Science  29 Apr 1966:
Vol. 152, Issue 3722, pp. 656-657
DOI: 10.1126/science.152.3722.656


Two inbred strains of mice show a threefold difference in duodenal phosphatase activity at 11 days of age. When half-litters of the two strains are interchanged between the two mothers on the day of birth, enzyme activity in young of the low-activity strain is unaffected at 11 days by the source of milk, but is significantly reduced in high-activity young nursed by a low-activity mother.