Antiserum to Immunoglobulin A: Inhibition of Cell-Mediated Demyelination in Tissue Culture

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Science  01 Jul 1966:
Vol. 153, Issue 3731, pp. 75-76
DOI: 10.1126/science.153.3731.75


Lymph node cells from rats immunized with sciatic nerve in Freund's adjuvant demyelinate trigeminal ganglion cultures. Rabbit antiserum to rat immunoglobulin A blocks this cytodestructive event. The antiserum may act by combining with IgA on the lymphoid cell surface, preventing the interaction of cell-bound antibody and tissue anitigen.