Inhibitory and Facilitatory Effect of Two Related Peptides on Extinction of Avoidance Behavior

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Science  15 Jul 1966:
Vol. 153, Issue 3733, pp. 318-320
DOI: 10.1126/science.153.3733.318


The polypeptide chain which constitutes the first ten amino acids of the ACTH molecule inhibits extinction of a shuttle-box avoidance response. If the phenylalanine molecule in the 7th position of this peptide is replaced by its dextrorotatory form, extinction is facilitated.

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