Feedback Inhibition of Glycerol Kinase, a Catabolic Enzyme in Escherichia coli

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Science  12 Aug 1966:
Vol. 153, Issue 3737, pp. 755-757
DOI: 10.1126/science.153.3737.755


Fructose-1 ,6-diphosphate is a feedback inhibitor of the catabolic enzyme, glycerol kinase, in Escherichia coli. A mutant was isolated which produced a desensitized enzyme. Glucose was no longer as effective in preventing the utilization of exogenous glycerol by cells which synthesized constitutively such an altered enzyme, even though the usual degree of catabolite repression still operated.