Infrared Analysis of Rat Bone: Age Dependency of Amorphous and Crystalline Mineral Fractions

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Science  23 Sep 1966:
Vol. 153, Issue 3743, pp. 1523-1525
DOI: 10.1126/science.153.3743.1523


Quantitative infrared spectrophotometric analysis of whole femurs from male rats demonstrates that anorphous calcium phosphate is a major component of bone mineral. The amount of amorphous calcium phosphate in whole bone decreases while the crystalline bone apatite increases during early stages of bone formation. Mature rat bone contains constant levels of both amorphous and crystalline calcium phosphate.